- Input: a target structure, optionally with specified hotspot or epitope residues.
- Output: candidate binder or antibody structures, each with interface confidence and quality scores.
Binder Design
Binder Design
End-to-end de novo binder and antibody design pipelines
Design protein binders and antibodies against a target structure. These end-to-end pipelines
generate a candidate backbone, design a sequence for it, and score the resulting interface,
repeating the loop to produce binders that engage the target. The outputs are computational
candidates intended for downstream evaluation and experimental testing.
Arc Institute